Background: The long-term success of endodontically treated teeth depends on the ability of restorative materials to withstand functional forces and prevent fracture. Bioceramic-based materials have emerged as potential alternatives for restoring teeth due to their biocompatibility, sealing ability, and mechanical properties. This study evaluates the fracture resistance of endodontically treated teeth restored using bioceramic-based materials compared to conventional restorative materials. Materials and Methods: This in vitro study involved 60 extracted human premolars randomly divided into three groups (n=20 each): Group A (restored with a bioceramic sealer and core material), Group B (restored with composite resin), and Group C (control, no restoration). Standardized endodontic treatment was performed on all samples. Each tooth underwent thermocycling for aging simulation, followed by load application at a 45° angle in a universal testing machine until fracture. The maximum load at fracture (in Newtons) was recorded and analyzed using ANOVA and post hoc tests (p<0.05). Results: The fracture resistance values were significantly higher in Group A (1200 ± 150 N) compared to Group B (950 ± 100 N) and Group C (700 ± 80 N). Post hoc analysis revealed that bioceramic-based materials provided superior reinforcement to endodontically treated teeth. Failure modes predominantly involved favorable fractures in Group A, while Groups B and C exhibited higher rates of catastrophic fractures. Conclusion: Bioceramic-based restorative materials significantly enhance the fracture resistance of endodontically treated teeth compared to composite resin and untreated teeth. These materials could be considered a promising choice for the reinforcement of weakened dental structures. Further clinical studies are recommended to validate these findings.