Background: Inflammatory Bowel Disease (IBD) is a chronic disease occurs by an incorporation of multiple factors. IBD isconsist of intestinal disorders and extra-intestinal manifestations of illnessthat leads long time inflammation of the digestive tract and is usually associated with anxiety and depression. Aims and Objectives: Comparative study to check the effect of yoga interventions on depression & anxiety in inflammatory bowel disease patients. Materials and Methods: Data for the present study were collected from inflammatory bowel disease patients in the age range of 20-40 years of both genders those attendingOPD of Gastroenterology department of S.M.S. Medical College and Hospital; Jaipur. An equal number of IBD patients from OPD of the Gastroenterology Department had considered as the control they did not undergone any yoga interventions. Results: There found significantly decrease in depression score after 6weeks and 12 weeks of yoga. No significant change found in anxiety score. Conclusion: The values of changes in depression show highly significant effect of yoga on quality of health and depression score of IBD patients.