Introduction- The frequency of uterine fibroids varies because the majority of patients have no symptoms; however, menorrhagia and iron deficiency anaemia, which can cause persistent fatigue, are the most common clinical features that prompt women to seek therapy. The present study was conducted to compare the effect of ullipristal, mifepristone and fibronorm in uterine fibroids. Material and methods- The prospective cohort study was conducted at department of obstetrics and gynecology among 150 patients diagnosed with uterine fibroids who visited the outpatient clinic during the study period of one year.Group A were those who received ullipristal, group B received mifepristone and group C received fibronorm having 50 patients in each group. The outcome analyzed were mean age, loss of menstrual blood by Pictorial blood loss assessment chart (PBAC) and fibroid size and symptoms pre and post study. Results – The mean age of patients in our study was between 35 to 45 years among three groups.The value of mean PBAC post study was 154.22±40.7 for group A, 134.23±38.5 for group B and 140.21±41.2 for group C and results were significant with p value 0.006. There was significant decrease in fibroid size and fibroid volume after the study among all the three group with p value <0.001. Conclusion – Treatment of uterine fibroids by three drugs was associated with reduction in fibroid size, reduced blood loss and fibroid volume but ullipristal acetate was more beneficial in case of large size of fibroids.