Appendicitis is a disorder that causes inflammation of the appendix, a little finger-shaped organ found in the lower right abdomen. While appendicitis appears to be a somewhat common medical issue, the complexities of the condition, as well as the difficulties in diagnosing it, have sparked significant medical attention. Aim: The aim of the present is to evaluate the Appendicitis Inflammatory Response (AIR) score in the case of suspected appendicitis and compare the scores with histopathological report to find out the sensitivity and specificity of the scoring system. Materials & methods: Researchers from Jaipur Golden Hospital's General and Minimal Invasive Surgery Department set out to determine the efficacy of the AIR Score for the diagnosis of acute appendicitis. Ultrasonography, laboratory investigations, and clinical examination were used to examine 110 male and female patients in the study. The pathologists analyzed samples retrieved from the appendix after patients with verified acute appendicitis underwent either an open or laparoscopic appendectomy. Approval from the IEC was granted to the investigation. Results: Among the 110 patients, 96 patients confirmed to have appendicitis through HPE, the AIR score classified 91 (94.79 %) as high-risk subjects were confirmed to have appendicitis by HPE. We observed a statistically significant difference between the AIR score, and the HPE diagnosis of appendicitis. The sensitivity of the AIR score was 95 % and the specificity of The AIR score was 82 %. Correspondingly, both false-positive was 21 % and false-negative was 5 % rate. The positive and negative predictive values of the AIR score were 97 % and 69 %. Conclusion: The AIR score enhances diagnostic capabilities for urgent surgical intervention, with superior validity and reliability, but further research is needed to understand variations within specific population groups.