Backgroud: Scoring systems have been developed in response to an increasing emphasis on the evaluation and monitoring of health services. These systems enable comparative audit and evaluative research of intensive care. The Present study conducted to assess the presenting APACHE II score and SOFA score of patients admitted in ICU with sepsis. Materials and Methods: This prospective study was undertaken over an 18-month period and included all the admissions which fit the inclusion criteria. APACHE II Score was calculated at 24 hours of admission to ICU using the worst value of 12 variables. SOFA Score was calculated on admission, at 48 hours and at 72 hours. Result: 60.1% study participants survived after 30 days. The patients who survived had a SOFA score at admission ranging from 2.70 to 8.09, which was statistically significant (P<0.01*). After 48 hours of admission, the SOFA score was 2.94 among survivors and 8.47 among non-survivors, which was also statistically significant (P<0.01*). After 72 hours of admission, the SOFA score was 2.94 among survivors and 8.40 among non-survivors, with a statistically significant difference (P<0.01*). On the other hand, the APACHE II Score ranged from 4.00 to 17.20 among survivors and non-survivors, with a statistically significant difference (P<0.01*). Conclusion: In conclusion, the study found that both SOFA and APACHE II scores effectively predict morbidity and mortality in critically ill patients, but SOFA scores showed a more pronounced difference between survivors and non-survivors. Using SOFA scores in conjunction with APACHE II scores may provide a more comprehensive assessment of patient severity and prognosis, highlighting the importance of validated scoring systems in informing clinical decision-making in intensive care units.