Background: Birth asphyxia is a common neonatal problem contributing to mortality and morbidity. Electrolyte disturbances and acute kidney injury (AKI) are common complications. Objective: To study electrolyte disturbances in newborns with birth asphyxia and its association with AKI. Methods: Newborns with birth asphyxia (>34 weeks gestational age) were included. Asphyxiated neonates were grouped by 1-minute Apgar score: mild (6-7), moderate (4-5), and severe (≤3). They received standard NICU care. Serum electrolytes, blood urea, and creatinine were monitored at 24 hours and 72-96 hours. Urine output was tracked using collection bags or catheterization. Electrolyte disturbances and AKI were classified using serum electrolyte levels and p-RIFLE criteria. Results: A total 56% male and 44% female participants, with 42% having low birth weight. Sodium and potassium disturbances were common, but not statistically significant in mild and moderate asphyxia cases. Acute kidney injury (AKI) occurred in 1.15% of cases, with a significant association found in mild asphyxia cases (P<0.01). Potassium levels were significantly associated with AKI (P=0.001), but sodium levels were not. Conclusion: Electrolyte disturbances are common in newborns with birth asphyxia, but not significantly associated with asphyxia severity. In this study AKI is a significant complication, observed asphyxiated in newborn. Early detection and management of electrolyte disturbances and AKI are crucial in improving outcomes.