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Volume 13 Issue 12 (December) 2024

Original Articles

Small myxoid spindle cell tumors in adults – A diagnostic enigma
Dr. Supriya Siddavattam, Dr. B. Krishnamoorthi Adiga

Background: The term “spindle cell tumors” is commonly used by pathologists for neoplastic lesions when it is difficult to find the lineage of differentiation without ancillary studies like immunohistochemistry. The spindle cell tumors encompass a broad, heterogeneous group of diverse histogenesis and of different grades with a higher risk of malignancy when tumor size is more than 5 cm. Although the malignant soft tissue tumors account for approximately 1% of adult cancers, the malignancy rate among soft tissue lesions of less than 5 cm accounts for approximately 23% (Felix GG et al.). The T1 stage of malignant tumors is defined by the American Joint Committee on Cancer (AJCC) as a lesion with a diameter < 5 cm. As the smaller tumors are likely assumed to be benign clinically and excised without adequate resection margins, preoperative cytological assessment plays a pivotal role in the triage of patients and early clinical decision-making. A variety of spindle cell tumors are associated with myxoid matrix augmenting diagnostic perplexity (Akshay DB et al.).

 
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