Background:Globally, diabetes mellitus (DM) is a significant public health concern. Recent estimates indicate that 7.3% of Indians suffer with DM. Individuals with diabetes mellitus are more likely to experience mental health issues. The present study was conducted to assess prevalence of depression in T2DM and associated risk factors.Materials & Methods:150 type II diabetes mellitus patients of both genders were selected. Post-Prandial Plasma Glucose (PPG), and glycatedhaemoglobin (HbA1c) were performed. The severity of depression was determined using Hamilton Depression Rating Scale (HAM-D).Results:Out of 150 patients, 86 were males and 64 were females. Type of family was joint: nuclear seen I 32:13 in patients with depression and 73:32 in patients without depression. Smoking was seen in 9 and 29, alcoholism in 3 and 11, duration of DM was 10.2 years and 11.3 years, family history of T2DM was seen in 5 and 16 and insulin therapy was seen in 12 and 18 respectively. The difference was significant (P< 0.05). The mean FPG (mg/dL) was 218.4 and 194.2, PPG (mg/dL) was 284.2 and 215.3, HbA1c % was 9.5 and 8.6 and haemoglobin (gm/dL) was 10.5 and 11.4 in patients with depression and without depression. The difference was significant (P< 0.05).Conclusion: Most of the patients had depression. Risk factors were smoking, alcoholism and family history of DM.