Introduction: Neuromuscular dysfunction is caused by hypothyroidism. The length of time and severity of the hormone insufficiency are associated with the severity of neuromuscular signs and symptoms.Hypothyroidism frequently causes peripheral neuropathy and polyneuropathy due to axonal damage or nerve demyelination.Since hypothyroidism can result in both myopathy and neuropathy, the purpose of the study was to evaluate the functional state of skeletal muscle and examine how hypothyroidism affects motor nerve transmission. Methodology: This study was done as a case control Study. The current investigation was carried out for a year in the Department of Physiology's Neurophysiology Research Laboratory. There are 60 people in all, 30 of them are in the study group and the remaining 30 are in the control group.Nerve conduction was investigated using the Medicare Systems (RMS) EMG EP MARK-II MACHINE. Results: In comparison to the control group, the hypothyroid group's mean values for the right and left median nerve conduction velocities were lower. However, there was no discernible difference between mean values for the right and left median nerve conduction velocities. The hypothyroid group's mean handgrip strength (kg) in the right upper limb was statistically significant lower than that of the control group. There was no statistically significant in the left upper limb. The hypothyroid group's mean values for the right and left upper limb HGE were lower than those of the control group, and this difference was statistically significant. Conclusion: Our findings have led us to the conclusion that hypothyroidism is associated with myopathy and neuropathy of the median nerve. The longer the condition lasts, the more severe the neuropathy and myopathy become. Early diagnosis of myopathy is crucial to preventing muscle deterioration and ensuring quality of life in hypothyroid individuals, as myopathy develops earlier than neuropathy.