Background: Medical education is evolving rapidly. With the introduction of Competency Based Medical Education (CBME) curriculum, the need for different and innovative methods of teaching and learning is increasing. This study investigates the effectiveness of a mobile App (CBME pill) in comparison to conventional teaching methods in undergraduate pharmacology curriculum. Methods: It was a crossover study in which 120 voluntary second year medical students were enrolled. All were given a lecture on topic 1 and then subjected to self-directed learning session half with conventional books and others with CBME pill App. The students were then crossed over for the second topic. Performance assessments were conducted in two phases, and feedback was collected from participants. Results: Results indicate that students in the CBME pill App group consistently achieved higher mean assessment scores compared to those in the conventional group, with statistically significant differences observed. The positive correlation between CBME pill percentage scores and feedback scores further supports the efficacy of CBME in improving student outcomes. These findings align with existing research demonstrating the effectiveness of mobile applications and self-directed learning in medical education. Feedback from participants was overwhelmingly positive, highlighting the benefits of the CBME pill App in enhancing curriculum implementation, motivation, and engagement. Conclusion: This student centric teaching-learning App contribute significantly to improving student learning outcomes and engagement in Pharmacology subject. This study also highlights the transformative potential of CBME pill App in reshaping the educational journey for medical students.