Numerous factors, such as the length of diabetes, proteinuria, hyperglycemia, genetic susceptibility, ethnicity, excessive protein intake, massive obesity, hypertension and a family history of renal disease, have a role in the development and progression of diabetic nephropathy. Also, systolic blood pressure, hyperangiotensinemia and hyperaldosteronism showed to be independent predictors of more vigorous decline in renal function. Background – End-stage renal disease (ESRD), which affects both Type 1 and Type II diabetics, is most frequently caused by diabetes. In both Type 1 and Type II diabetes, 20 to 30% of patients show signs of nephropathy, but a much smaller percentage of Type II diabetes patients go on to develop end-stage renal disease (ESRD). Aim and objective – Persistent proteinuria, hypertension, and a progressive loss in renal function are the hallmarks of diabetic kidney disease (DKD), a potentially fatal and irreversible micro-vascular consequence. Microalbuminuria, often known as early DN1-4, or a slight rise in urine albumin excretion (UAE) are characteristics of the early stage. As it is known that diabetes mellitus causes major macro vascular and micro-vascular consequences, a significant portion of the related morbidity and mortality are caused by micro-vascular consequences of diabetes mellitus Therefore, the purpose of the current study was to ascertain the relationship between nephropathy development in type II diabetics and its duration. Methodology –This study was conducted in Department of General Medicine, Government General Hospital, Ananthapuram, over a period . All patients presenting to General medicine OPD and patients admitted in the medical wards were included in the study. Type II diabetes is considered in case of Patients who developed diabetes after the age of 30 years . Albuminuria in diabetic people is regarded as nephropathy. Results - Duration of diabetes- Most patients with type II diabetes will have end organ dysfunction with micro macro-vascular complications staring at even the time of diagnosis of disease rather than type I diabetes where it takes years to develop complications .Therefore, it is important to screen for organ dysfunction at an increasing frequency as the disease progresses through years. Conclusions – Early screening for urine albumin excretion predicts early development of renal dysfunction thereby providing us a chance for intervening in between and thereby preventing further progression to end stage renal dysfunction , which is life threatening and may require renal replacement therapy .