Background: Trauma remains a significant cause of mortality and morbidity worldwide, with varying mortality rates depending on the severity and nature of injuries sustained. Efficient assessment of injury severity using appropriate scoring systems is crucial for guiding trauma management and predicting patient outcomes. Various scales, such as the Trauma and Injury Severity Score (TRISS) and Glasgow Coma Scale (GCS), are employed to assess physiological and anatomical aspects of trauma severity. Aim: This prospective cohort study aimed to compare and contrast the predictive efficacy of TRISS and GCS in determining mortality among trauma patients presenting at the casualty department of Shri B. M. Patil Medical College Hospital and Research Centre, Vijayapura, India. Materials & Methods: Over a period from August 2022 to July 2024, 50 trauma patients aged over 13 years were enrolled. Exclusion criteria included outpatients, patients treated for less than 6 hours, and those with pre-existing chronic conditions. Data collection involved assessing each patient using the aforementioned severity scales upon admission. Results: The study cohort had a mean age of 35 years, with females comprising 83% of patients. Head and Necktrauma was most prevalent, followed by Abdomen. Moreover, deceased patients exhibited significantly lower GCS, and along with higher TRISS scores, which showed AUC for ROC analysis of 0.83. Conclusion: The findings underscore the utility of GCS and TRISS in predicting mortality among trauma patients. Lower scores on physiological severity scales were associated with better survival outcomes, emphasising the importance of early and accurate assessment using these tools in trauma care. Further research should explore their applicability across diverse trauma.scenarios to enhance clinical decision-making and improve patient outcomes.