Background: The frequent direct contact with patients and performing aerosol-generating procedures make Anaesthesiologists prone to risk during epidemics and pandemics. Government-imposed containment measures lead to social isolation and psychological distress.The primary objective was to assess mental health outcomes among qualified anaesthesiologists involved in COVID-19 care across Pondicherry, secondary objective was to assess the coping strategies used. Methods: We conducted an online observational, cross-sectional, single response study among qualified Anaesthesiologists who were actively involved in COVID-19 patient care across Pondicherry. After obtaining institutional ethical committee clearance, the voluntarily participating Anaesthesiologists were administered a Google forms-based closed-ended questionnaire via e-mail. Sociodemographic, workplace and perception characteristics were assessed. Mental status outcomes assessment was done using DASS-21 questionnaire and Coping Strategies Inventory – Short Form. Results: Among 118 respondents, the overall prevalence of depression, anxiety and stress was 38.9%, 41.6% and 18.6% respectively. Among those who participated in our study, 4.4%, 10.6% and 9% were found to have extremely severe (depression, anxiety and stress) respectively. Receiving a quarantine order was found to be statistically significant for depression (P < 0.040). Non-conducive work environment (P < 0.040), 8-14 days of posting in COVID ward (P < 0.040) and more than ten years work experience (P = 0.040) were statistically significant for anxiety. Statistically significant for stress were, children at home (P < 0.008), receiving a quarantine order (P < 0.040) and more than ten years work experience (P = 0.040). Conclusion: Screening, and providing support to anaesthesiologists identified with having mental health issues is crucial.