Background: Knee osteoarthritis (OA) is classified as either primary or secondary, depending on its cause. In addition to a thorough history and physical, radiographic imaging is required. The present study was undertaken for carrying out the clinical assessment of patient of osteoarthritis knee for optimum outcome in total knee replacement. Materials & methods: To evaluate the importance of clinical assessment of patients of osteoarthritis knee for optimum outcome in Total Knee Replacement, the present study was conducted on 20 patients. Inclusion criteria for the present study included patients with Primary or Secondary arthritis with or without deformities who has already undergone TKA. For clinical and radiological assessment of patients of osteoarthritis knee the following criteria were assessed by Knee Society Score. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: The preoperative Femur-tibia angle was 183.1 degree while postoperative Femur-tibia angle was 174.9 degree. On comparing statistically, significant reduction in Femur-tibia angle postoperatively was seen. Mean preoperative KSS was 119.2 while postoperative KSS was found to be 218.3. Comparing the results statistically, significant increase in KSS postoperatively was seen. Conclusion: Total knee replacement is a reliable and safe modality of treatment and can be performed with results comparable to the other global studies provided there is adequate expertise and follow up by the patient to detect any complications early, before they occur.