Background:In recent years, there has been a significant shift in the method used to diagnose prostate cancer. The focus is on radical prostatectomy, which is thought to cure the disease, and early diagnosis when the process is still limited to the prostate. The present study was conducted to evaluate the serum PSA levels in patients presenting with enlarged prostate. Materials & Methods: Results:Out of 20 benign lesion, 45 (90%) were histologically confirmed. Out of 24 malignant lesions, 26 (92%) were histologically confirmed. Age group 40-49 years had PSA level of 0.61 ng/ml, 50-59 years had 2.1 ng/ml, 60-69 years had 2.4 ng/ml and 70-79 years had 2.8 ng/ml. The difference was significant (P< 0.05). Conclusion:Serum PSA levels can be used as a marker to monitor the advancement of prostate cancer and are an excellent predictor of the prostate's glandular expansion.