Aim: This study aimed to investigate the impact of ocular microbial infections on psychiatric symptoms in patients with chronic eye diseases, including glaucoma, diabetic retinopathy, and age-related macular degeneration. Materials and Methods: A total of 80 patients with chronic eye diseases and a history of ocular microbial infections were enrolled. The study was conducted in an outpatient ophthalmology clinic, and psychiatric symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and the Positive and Negative Syndrome Scale (PANSS). Ocular infections were diagnosed based on clinical signs and microbiological cultures. Statistical analysis was performed using SPSS software to explore correlations between infection severity and psychiatric symptoms. Results: The study revealed that 62.5% of patients experienced depressive symptoms, with nearly 40% having moderate to severe depression. A significant correlation was found between the severity of ocular infections and the worsening of depressive and negative psychiatric symptoms. Fungal and mixed infections were associated with the highest HDRS scores, indicating more severe depression. Additionally, patients with more severe ocular infections exhibited higher scores for both positive and negative psychiatric symptoms on the PANSS. Conclusion: This study demonstrates a significant association between ocular microbial infections and the exacerbation of psychiatric symptoms in patients with chronic eye diseases. The severity of ocular infections was linked to increased levels of depression and negative symptoms, particularly in cases of fungal and mixed infections. These findings highlight the importance of integrated care that addresses both ocular and psychiatric health.