Background:Diabetic retinopathy (DR) constitutes a significant complication associated with diabetes mellitus (DM) and is recognized as a predominant cause of vision impairment among individuals of working age. Hence, the present study was conducted to assess risk factors profile of diabetic retinopathy. Materials &Methods:A cohort of 100 patients diagnosed with diabetic retinopathy (DR) and an equal number of control subjects were recruited for the study. Comprehensive demographic and clinical information were gathered for all participants. Data collection was facilitated through a specially designed questionnaire that encompassed demographic variables such as gender and age, as well as aspects of metabolic control, diabetes mellitus (DM) profile, and associated comorbidities. Clinical records were initially reviewed to ascertain the presence or absence of DR, as determined by an ophthalmologist based on clinical observations validated through both direct and indirect ophthalmoscopy, in accordance with the international clinical diabetic retinopathy disease severity scale. Additionally, various risk factors linked to the development of DR were assessed. Results:The mean age of the patients of the study group and control group was 51.3 years and 48.2 years respectively. There were 62 males and 38 females in the study group and there were 66 males and 34 females in the control group. Positive family history of diabetes was seen in 43 patients of the study group and in 12 patients of the control group. 65 percent of cases of study group had mild NPDR while 23 percent had moderate NPDR.Geriatric age, presence of dyslipidemia, hypertension & obesity along with positive family history of diabetes were found to be significant risk factors for occurrence of DR. Conclusion:Diabetes mellitus is a complex metabolic disease with DR being one of its significant complications associated with significant morbidity. It is not possible to define which diabetic individuals will present retinopathy. However, it is possible to determine risk factors related to the development of retinopathy.