Background: In Pregnancy changes in ECG pattern and cardiovascular events are recorded. It was also reported that changes in both during pregnancy can produce severe complications. It is very important to manage the complications in different trimesters to reduce mortality. Methodology: Total 300 study subjects were enrolled in the study. 150 were non pregnant and 150 were pregnant of different trimesters. Subjects were investigated for ECG, blood pressure, heart rate, pulse rate, mean systolic blood pressure, mean diastolic blood pressure, and mean arterial pressure. All the readings were recorded. Results: This was observed that pulse rate, mean systolic blood pressure and mean arterial blood pressure was raised in pregnant women in different trimesters when compared with non-pregnant. In ECG findings short PR interval was significantly more according to the trimesters than non-pregnant women (p<0.05). Conclusion: This can be concluded that in pregnancy both cardiovascular changes as well as changes in ECG pattern can be recorded in different trimesters that can help to manage the complications during pregnancy.