Aim: The aim of the study to assessment the quality of life in patients with chronic kidney disease . Method : This study included 100 CKD patients and used a systematic random sampling method for quantitative analysis. Chi square and ANOVA were used to draw comparisons between two groups or more than two groups, respectively. Logistic regression analysis was utilized to identify the potential QoL determinants. A p value of 0.05 or lower was used to determine statistical significance. Result : Among a total of 100 participants, the mean (±standard deviation) age was found to be 54.53 ± 13.47 years; 40 were male patients, and 60 were female patients. Diabetes Mellitus (60.9%), hypertension (55.2%), chronic glomerulonephritis (7.5%), chronic pyelonephritis (6.4%), and polycystic kidney disease (5.5%) were identified to be the most frequent disorders associated with CKD. The current study also demonstrated that the HRQOL score domains such as symptom problem list, the effect of kidney disease, and the burden of kidney disease decline significantly and progressively as the patient advances into higher stages of CKD (p = 0.005). A similar pattern was observed in work status, sleep, and general health (p < 0.005). This study also revealed that CKD imposes various restrictions on patients’ day-to-day lives, particularly in terms of their physical and mental functioning, even in the initial stages of the disease. Conclusion : This study demonstrated that a significant decrease in HRQOL was observed among CKD patients, with a progressive deterioration of HRQO L dimensions as the patient advances to end-stage renal disease. This study also revealed that CKD imposes various restrictions on patients’ day-to-day lives, particularly in terms of their physical and mental functioning, even in the initial stages of the disease.