Background: In major surgeries, endotracheal intubation has been proved to be the most effective way to maintain and secure airway. The present study evaluated drugs Esmolol, Diltiazem and combination of Esmolol and Diltiazem to see haemodynamic response to laryngoscopy and intubation. Materials & Methods: 90 patients were randomly divided into three Groups - D, E and combination group (D+E) of 30 each by using a closed envelope method. GROUP D (30 patients): received Diltiazem I/V (0.2 mg/kg), group E (30 patients): Esmolol I/V (1.5 mg/kg), group D+E (30 patients): Combination of Diltiazem (0.1 mg/kg) and Esmolol (0.75 mg/kg). Results: There was significant difference (p <0.05) in heart rate at all intervals of time except for the base line values. There was significant difference (p <0.05) in systolic BP at all intervals of time except for the base line values. A reduced diastolic BP in combination group compared to the diltiazem and esmolol group after laryngoscopy which is denoted by a significant p value (p <0.05). Conclusion: A combination for drug esmolol and diltiazem in minimal effective doses can be used safely for attenuating hemodynamic responses during laryngotracheal intubation.