Background: This study aims to evaluate thyroid dysfunction in patients with liver cirrhosis and its association with the severity of liver disease using Child-Pugh and Model for End-Stage Liver Disease (MELD) scores.Materials and Methods: This cross-sectional study was conducted at a tertiary care hospital, including 100 patients diagnosed with liver cirrhosis. Patients underwent a detailed clinical evaluation, including medical history, physical examination, and laboratory investigations. Thyroid function was assessed by measuring serum levels of thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). Liver function tests and severity assessment using Child-Pugh and MELD scores were performed. Statistical analysis was conducted to evaluate correlations between thyroid dysfunction and liver disease severity.Results: The study included 100 cirrhotic patients, with a mean age of 52.4 ± 10.8 years, of whom 68% were male. The most common comorbidities were diabetes mellitus (30%) and hypertension (40%). Thyroid function analysis revealed that 20% of patients had subclinical hypothyroidism, 10% had overt hypothyroidism, and 10% had low T3 syndrome. The mean FT3 (2.1 ± 0.5 pg/mL) and FT4 (0.88 ± 0.25 ng/dL) levels were lower than normal. A significant negative correlation was found between FT3, FT4 levels, and Child-Pugh (r = -0.50, -0.45) and MELD scores (r = -0.48, -0.42, respectively; p < 0.01), indicating worsening thyroid function with increasing liver disease severity.Conclusion: Thyroid dysfunction is prevalent in liver cirrhosis, with low T3 syndrome and hypothyroidism being the most common abnormalities. The significant negative correlation between thyroid hormone levels and liver disease severity suggests that thyroid dysfunction may serve as a potential prognostic marker for cirrhosis progression. Routine thyroid function screening in cirrhotic patients is recommended for early detection and management.