Aim: The aim of this study was to compare laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) in terms of recovery time, postoperative complications, and patient satisfaction in patients with symptomatic gallstone disease. Materials and Methods: This comparative study included 100 patients diagnosed with symptomatic gallstone disease, who were randomly assigned to undergo either LC (50 patients) or OC (50 patients). Inclusion criteria included patients aged 18–70 years with confirmed gallbladder pathology. Preoperative assessments included history-taking, physical examination, laboratory investigations, and ultrasonography. All surgeries were performed under general anesthesia by experienced surgeons. The primary outcomes were recovery time (hospital stay and return to normal activity) and complications (wound infection, bile leakage, bleeding, and postoperative pain). Follow-up assessments were conducted at 1 week, 1 month, and 3 months. Results: The recovery time was significantly shorter in the LC group, with a mean hospital stay of 1.6 ± 0.8 days compared to 4.2 ± 1.1 days in the OC group (p < 0.001). LC patients returned to normal activity in 5.2 ± 2.3 days, while OC patients took 12.7 ± 3.4 days (p < 0.001). Postoperative pain was significantly higher in the OC group, with 30% of OC patients experiencing severe pain compared to 10% in the LC group (p = 0.02). At the 3-month follow-up, 96% of LC patients reported complete recovery, compared to 90% of OC patients (p = 0.35). Patient satisfaction was significantly higher in the LC group, with 96% reporting excellent or good satisfaction compared to 80% in the OC group (p = 0.04). Conclusion: Laparoscopic cholecystectomy offers significant advantages over open cholecystectomy, including shorter hospital stays, faster recovery, reduced postoperative pain, and higher patient satisfaction. These results suggest that LC should be considered the preferred surgical approach for patients with symptomatic gallstone disease due to its minimal invasiveness and quicker recovery.