Background: Excessive and prolonged alcohol consumption can result in the development of dependence, which is characterized by a withdrawal syndrome upon the cessation or significant reduction of alcohol intake. Hence; the present study was conducted for assessing gamma glutamyl transferase (GGT) and psychiatric comorbidity in association with alcohol dependent patients. Materials & methods: The A cohort of 100 male individuals, aged between 18 and 60 years, who met the diagnostic criteria for alcohol dependence as outlined in the International Classification of Diseases, 10th Edition (ICD-10) for research purposes (World Health Organization, 1993), was selected for this study. Individuals with a history of any systemic illnesses or known drug allergies were excluded from participation. Each participant underwent a structured clinical interview to confirm the diagnosis of alcohol dependence, in addition to completing the Alcohol Use Disorder Identification Test (AUDIT) to assess their alcohol consumption patterns. Furthermore, blood samples were collected, and both electrocardiograms (ECG) and ultrasonograms were performed. The data were analyzed using SPSS software, with the Chi-square test employed to determine the significance of the findings. Results: Psychiatric co-morbidity was seen in 83 percent of the patients. Anxious avoidant, Nicotine dependence, Anxiety disorder, Depression and Schizophrenia was seen in 18.07 percent, 12.05 percent, 25.3 percent, 22.89 percent and 9.64 percent of the patients respectively. Mean GGT levels among patients with and without psychiatric co-morbidity was 1195 U/L and 69.2 U/L respectively. significant results were obtained while comparing GGT levels among patients with and without psychiatric co-morbidity. Conclusion: The Gamma-glutamyl transferase (GGT) level can play a crucial role in the accurate identification of Alcohol use disorder patients with psychiatric comorbidity thereby facilitating the equitable management of related cases. It offers valuable motivational support to affected individuals.