Introduction: Type 2 diabetes is a growing health concern, and early detection is crucial for effective management.It’s been demonstrated in few recent studies that the abnormal levels of adipocytokines (Adiponectin, leptin) can contribute to IR and type-2 diabetes. Objective: This study aimed to investigate the relationship between insulin resistance, adiponectin, and leptin in type 2 diabetes patients and healthy controls. Material and Method: A total of 180 participants (120 patients and 60 controls) were enrolled in this study. Demographic and clinical profiles were compared between the two groups. Correlations between insulin resistance, adiponectin, and leptin were analysed, and optimal cutoff values were determined. Result: Patients had higher mean BMI, fasting blood sugar, postprandial blood sugar, total cholesterol, triglycerides, LDL, and VLDL, and lower mean HDL. Insulin resistance was positively correlated with adiponectin and leptin. The optimal cutoff values for insulin resistance, adiponectin, and leptin were 2.40, 17.22, and 18.75, respectively.At these cutoff values, insulin resistance and adiponectin showed perfect sensitivity and specificity (100% each), resulting in an accuracy of 100%. Leptin, on the other hand, showed a sensitivity of 80%, specificity of 55%, and accuracy of 74.9%. Conclusion: This study highlights the importance of insulin resistance, adiponectin, and leptin as biomarkers for type 2 diabetes. Early detection and management of insulin resistance and related metabolic abnormalities are crucial for preventing the development of type 2 diabetes and its complications. This study provides valuable insights into the pathophysiology of type 2 diabetes and has implications for the development of novel therapeutic strategies.