Background: In primary teeth, pulp inflammation is mostly caused by tooth decay and acute dental accidents. The present study was conducted to assess photodynamic therapy for endodontic treatment of primary teeth. Materials & Methods: 60 primary anterior teeth with a diagnosis of pulp necrosis were taken. Group I, patients undergoing conventional root canal therapy (n = 30) and group II, patients undergoing conventional root canal therapy combined with antimicrobial PDT (n = 30). Reduction of bacterial loadwas recorded. Results: In group I, there was 94% and in group II 99% reduction of bacterial load. The difference was significant (P< 0.05). Conclusion: According to the study's parameters, conventional therapy plus antimicrobial PDT was successful, but it was just as effective as conventional endodontic treatment by itself.