Background: Chronic kidney disease (CKD) is characterized by progressive loss of kidney function and is associated with significant alterations in lipid metabolism and uric acid levels. These biochemical abnormalities contribute substantially to the elevated cardiovascular risk observed in CKD patients. Objective: This study aimed to evaluate the relationship between lipid profile parameters, serum uric acid levels, and disease progression in patients with varying stages of CKD. Methods: A cross-sectional study was conducted involving 120 CKD patients categorized by disease stage (1-5) according to estimated glomerular filtration rate (eGFR). Fasting blood samples were analyzed for total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and serum uric acid. Results were compared across CKD stages and correlated with renal function parameters. Results: Significant dyslipidemia was observed with advancing CKD stages, characterized by increased TC, TG, and LDL-C, with concurrent decreases in HDL-C. Serum uric acid levels progressively increased with declining renal function (p<0.001). Multivariate analysis revealed that elevated uric acid levels independently correlated with dyslipidemia patterns (r=0.68, p<0.001) and were predictive of faster CKD progression. Conclusion: Both dyslipidemia and hyperuricemia worsen with advancing CKD and appear to have synergistic effects on disease progression and cardiovascular complications. Early monitoring and management of these metabolic abnormalities may be crucial in slowing CKD progression and reducing cardiovascular risk.