Background: As the prostate enlarges, it can obstruct the flow of urine from the bladder, which may result in lower urinary tract symptoms.The aim of this study was to compare the efficacy, safety, and postoperative outcomes of Holmium Laser Enucleation of the Prostate (HoLEP) and Bipolar Transurethral Resection of the Prostate (B-TURP) in patients diagnosed with Benign Prostatic Hyperplasia (BPH). Materials and Methods: This was a prospective, randomized controlled trial involving 100 male patients aged between 50 and 80 years, diagnosed with symptomatic BPH. Patients were excluded if they had a prostate volume greater than 100 ml, urinary retention requiring catheterization, active urinary tract infections, prostate cancer, or significant comorbidities. The patients were randomly assigned to either the HoLEP group (50 patients) or the B-TURP group (50 patients) using a computer-generated random number sequence. Preoperative evaluation included a detailed medical history, physical examination, digital rectal examination, serum PSA levels, urinalysis, renal function tests, and ultrasonography of the prostate and bladder. Results: The demographic characteristics of patients in both groups were comparable, with no significant differences in age, prostate volume, or PSA levels. The HoLEP group had a significantly longer operative time (80 ± 10 minutes) compared to the B-TURP group (60 ± 12 minutes), and also experienced significantly less blood loss (180 ± 40 ml vs. 250 ± 50 ml). However, the HoLEP group had a shorter hospital stay (2.5 ± 0.7 days) and a shorter catheter removal time (2 ± 0.5 days) compared to the B-TURP group (3 ± 0.9 days and 3 ± 0.6 days, respectively). Postoperative complications were low and comparable between the two groups, with no significant differences in hemorrhage, clot retention, urinary infection, urinary retention, or incontinence. Both groups showed significant improvements in IPSS and QoL scores, with no significant differences between the two. Conclusion: Both Holmium Laser Enucleation of the Prostate (HoLEP) and Bipolar Transurethral Resection of the Prostate (B-TURP) are effective and safe surgical options for the treatment of Benign Prostatic Hyperplasia (BPH), providing similar functional outcomes and symptom relief. HoLEP offers advantages such as reduced bleeding and the ability to manage larger prostate volumes, while B-TURP provides shorter operative times and fewer complications.