Introduction: The aim of this study was to analyze the anatomical variations of depression, supraorbital notches and supraorbital foramina. When performing supraorbital endoscopic surgeries and regional nerve blocks, it is important to understand the exact location of the supraorbital fossa. Aim Migraine treatment, supraorbital endoscopic surgery, regional nerve blocks, and nerve compression all require an understanding of the location of the supraorbital nerve. This work discusses the emergent pathways of the supraorbital nerve and provides a comprehensive review of the literature of previous anatomical studies. Surgeons worldwide will benefit from this comparative analysis. Materials and Methods : The supraorbital notch and/or opening were bilaterally analyzed in 50 human dry skulls using a digital verniercaliper. The parameters taken in the study were the number of notches/openings and the distance of the supraorbital notch/opening from the nasion and the fronto-zygomatic suture. Results: The supraorbital notch is more common on the right side, occurring in 66% of cases compared to 50% on the left side. In contrast, the supraorbital foramen is slightly more common on the left side, with a prevalence of 46% compared to 30% on the right side. Correlation for nasion to right and left supraorbital feature distances is weak and not statistically significant.The Pearson correlation coefficient (r) is 0.245 and the significance value (p) is 0.086, which does not exceed the threshold of statistical significance (p < 0.05), that distances from the frontozygomatic suture to supraorbital features moderately predict distances on the other side. Conclusion: The superior orbital region is used in supraorbital nerve blocks for several procedures such as wound closure, biopsy, scar examination and other facial cosmetic procedures, so a thorough knowledge of this region is critical for physicians to effectively anesthetize the supraorbital nerve.