Background: In the post-operative phase, wound dehiscence is an unpleasant condition with high-risk complications that can result in mortality and morbidity. Materials & Methods: 80 patients with abdominal hernia of both genders were divided into 2 groups. Patients in group I had their fascia closed with Prolene, whereas those in group II had their fascia closed with Vicryl. On the third, fifth, seventh, and ninth post-operative days, follow-ups were conducted to monitor for infection. Results: Group I comprised of 21 males and 19 females and group II had 18 males and 22 females. Diagnosis was intestinal perforation seen in 8 in group I and 9 in group II, intestinal obstruction 4 in group I and 7 in group II, hemoperitoneum 12 in group I and 13 in group II, blunt trauma abdomen 6 in group I and 3 in group II, gut gangrene 5 in group I and 7 in group II, mass abdomen 5 in group I and 1 in group II. Procedure was elective 19 in group I and 18 in group II and emergency 21 in group I and 22 in group II. The difference was non- significant (P> 0.05). Group I had wound dehiscence seen in 8 and 14 in group II. The difference was significant (P< 0.05). Conclusion: Compared to absorbable Vicryl suture, Prolene has a better result and causes less wound dehiscences and other complications.