Aim: The present study aimed to assess the incidence and profile of neonatal dermatosis (ND) and its association with various perinatal risk factors in neonates presenting with skin lesions in atertiary care teaching hospital.Materials and methods: A cross-sectional observational study was conducted in the Department of Pediatrics, Base Hospital Delhi Cantt. over the duration of one year. After fulfilling the inclusion and exclusion criteria, 200 neonates were recruited for the study.Clinical performa including history, family history, anthropometry, detailed history of the symptoms and the dermatological examination of all the study subjects were carried out and data was recorded.Diagnosis of neonatal dermatosis was made by pediatrician after clinical examination and after dermatological consultation, whenever required.Results: The majority of neonates were born to mothers with age group 25-30 years (38.5%). Maximum patients were full term neonates 145 (72.5%).32.5% mothers of neonates were primiparous followed by parity one (32%).The 123 (61.5%) neonates were belong to birth weight group 2.6-3.5 kg. Majority of patients, 118 (59%) neonates were born by natural vaginal delivery. In 186 (93%) neonates history of consanguinity was not observed.The most prevalent Dermatosis in our study was Erythema Toxicum Neonatorum (24%) followed by Sebaceous Gland Hyperplasia (15%) and Mongolian Spots (10%).Sebaceous gland hyperplasia was significantly higher in post term neonates (26.70%)(p=0.04). Superficial desquamation was significantly higher in post term neonates (30%) (p=0.00).Erythema Toxicum Neonatorum (33.10%) and salmon patch (7.60%) was significantly higher in vaginally delivered neonates (p=0) (p=0.041) respectively. Mongolian Spots andSuperficialDesquamationwas significantly higher in neonates born with c section (p=0.021)(p=0.001) respectively. Milia was significantly higher in neonates having birth weight less than 1.5kg (40%) (p=0.01). Capillary hemangioma was significantly higher in neonates having birth weight more than 3.5kg (16.70%). (p=0.05).Conclusion: The study identified Erythema toxicum neonatorum, sebaceous gland hyperplasia and Mongolian Spots as prevalent cutaneous lesion. Parenteral Anxiety associated can be alleviated by accurately diagnosing these physiological and pathological conditions in neonates and counseling the parents; this prevents the need for unnecessary diagnostic testing and treatment.