Background: The aesthetic longevity of CAD/CAM restorative materials is influenced by surface roughness and color stability. Various staining agents encountered in daily life can impact these properties, potentially affecting clinical outcomes. This study evaluates the surface roughness and color stability of different CAD/CAM restorative materials after exposure to commonly consumed staining agents. Materials and Methods: Three CAD/CAM restorative materials—lithium disilicate glass-ceramic, hybrid ceramic, and zirconia—were selected for evaluation. A total of 60 specimens (n=20 per material) were fabricated and polished. Baseline surface roughness (Ra) and color values (CIE Lab*) were recorded using a profilometer and a spectrophotometer, respectively. The specimens were immersed in staining solutions (coffee, red wine, and cola) for 14 days, with distilled water as the control. Post-immersion measurements were taken, and statistical analysis was performed using ANOVA and Tukey’s post-hoc test (p<0.05). Results: Lithium disilicate exhibited the highest color change (ΔE=6.2±0.5) after exposure to red wine, followed by hybrid ceramic (ΔE=4.8±0.4) and zirconia (ΔE=3.1±0.3). Surface roughness increased significantly in lithium disilicate (Ra=0.54±0.02 µm) and hybrid ceramic (Ra=0.47±0.03 µm) after immersion in coffee, whereas zirconia demonstrated minimal changes (Ra=0.31±0.02 µm). Statistical analysis indicated significant differences among materials and staining solutions (p<0.05). Conclusion: Lithium disilicate and hybrid ceramics showed higher susceptibility to staining and surface roughness alterations compared to zirconia. Among the staining agents, red wine caused the most significant color change, while coffee led to increased surface roughness. Zirconia exhibited superior resistance to both parameters, making it a more durable option for long-term aesthetic restorations.