Background- Occupational sharps injuries are a serious hazard in any healthcare setting. Contact with contaminated needles, scalpels, broken glass, and other sharps may expose healthcare workers to blood that contains pathogens that pose a grave, potentially lethal risk. The cost of prophylaxis and post-exposure treatment is a significant institutional economic burden. In present study we aimed to estimate the prevalence, factors associated with sharp injuries and its cost burden on hospital. Material and Methods- Retrospective study of all reported cases of sharp injuries among HCWs for Jan. 2023 to Dec. 2023 in a tertiary care hospital. Direct & indirect cost was calculated as per CDC definition. Results & Discussion- Total 61sharp injuries were reported in last year (2023). Females were mostly affected. Doctors were affected the most. Most of the sharp injuries occurred in Emergency department. Maximum number of sharp injuries (6.39%) occurred during recapping the needle. The source was seropositive in 9 (14.75%), seronegative in 34(55.73%) and source was unknown in 18(29.51%). Total 534299 INR including direct and indirect costs. Conclusion- Regular surveillance and analysis of sharp injuries is very crucial in planning preventive measures and training requirements which takes care of safety of HCWs and reduces the economic burden on the institute.