Over the past three decades, regular blood transfusions and iron chelation have dramatically improved the quality of life and thalassemia is transformed from a rapidly fatal disease to a chronic disease and is compatible with prolonged life. Regular blood transfusion causes generalized iron overloading in organs such as heart, liver and pancreas. Lung impairment in thalassemia is also noted. All enrolled children were taken detailed clinical history including age at first blood transfusion, number of blood transfusion, duration of iron chelation therapy and General physical examination findings were recorded on a predesigned proforma. Total number of children with abnormal pulmonary function tests was 35(77.8%). Ten (22.2%) children had normal PFT. Among 35 children with pulmonary dysfunction, 31(88.5%) children had restrictive pattern, 2 (5.71%) children had Obstructive pattern and 2(5.71%) children had combined pattern. Mean age of children with abnormal PFT was 8.2± 2.4.