Aim: This study aimed to assess the postoperative complications in orthopedic surgeries and evaluate the associated risk factors and preventive strategies in a cohort of 100 patients. Materials and Methods: A prospective observational analysis was conducted at a tertiary care hospital. Patients aged 18 years and above, undergoing elective or emergency orthopedic surgeries, were included. Data on demographics, comorbidities, types of surgery, anesthesia, and postoperative complications were collected. Preventive strategies such as antibiotic prophylaxis and thromboprophylaxis were implemented. Statistical analysis included descriptive statistics and regression models to identify predictors of complications. Results: The study found that 60% of patients were male, with a mean age of 45.2 years and an average BMI of 28.4. Notably, 30% had diabetes and 40% had hypertension, both significantly associated with postoperative complications. The most common procedures were fracture fixation (40%) and joint replacement (30%). The most frequent postoperative complications were wound infections (10%) and delayed wound healing (8%). Preventive strategies were widely implemented, with antibiotic prophylaxis administered to 90% of patients and thromboprophylaxis to 85%. The effectiveness of preventive strategies was significant, reducing complications. Conclusion: Comorbidities such as diabetes and hypertension significantly increase the risk of postoperative complications in orthopedic surgeries. Preventive strategies, including antibiotic prophylaxis and thromboprophylaxis, were effective in reducing the incidence of complications. Early intervention and individualized care are essential to improving patient outcomes in orthopedic procedures.