Background: Benign vocal cord lesions are prevalent contributors to dysphonia and are frequently amenable to surgical intervention. These lesions encompass conditions such as vocal polyps, vocal cysts, vocal nodules, and Reinke’s edema. This was a Comparative Study of Different Techniques for Vocal Cord Lesion Removal and Their Impact on Voice Quality in Head and Neck Patients. Material and methods: 100 patients scheduled for removal of vocal cord lesions were enrolled. Complete demographic and clinical details of all the patients was obtained. A Performa was made and complete clinical findings of all the patients was evaluated. All the patients were randomized into two study groups- Laser treatment group [CO2 laser was used] and conventional laryngo-microsurgery group. All the patients underwent removal of vocal cord lesions according to their respective study groups. The voices of the patients were assessed before surgery as well as at 1 week, 1 month, and 3 months post-surgery. For the subjective assessment, patient’s self-assessment of voice disability Index (VHI) was used. All the results were compiled and compared. SPSS software was used for evaluation of results. Results: Mean VHI among patients of Laser group Before surgery, one week after surgery, one month after surgery and Three months after surgery was 35.1, 23.2, 18.9 and 8.3 respectively.Mean VHI among patients of Laser group Before surgery, one week after surgery, one month after surgery and Three months after surgery was 34.9, 24.9, 17.3 and 9.9 respectively. Non-significant results were obtained while comparing the two techniques at different time intervals. Conclusion: Both the study groups were comparable and had similar effect on voice quality in head and neck patients.