Background: Derangements of lipoprotein metabolism are a risk factor for several conditions apart from the most commonly associated cardio-metabolic disorders [1,2]. It has been demonstrated that high levels lipid panel markers of serum namely total cholesterol (TC), triglycerides (TG), LDL cholesterol, very-low-density lipoprotein (VLDL), low concentration of HDL cholesterol, along with increased body mass index (BMI) are significantly implicated in CHD [3].Aims: To assess the diagnostic profile of all lipid panel marker in the patients admitted in tertiary care rural hospital. Materials and Methods: Hospital based secondary data analysis from clinical records of IPD patients for whom lipid panel investigation was carried out during the period 2017 to 2018. A sample size of 300 was considered using prevalence of hypertension in the catchment area. The dataset of 300 patients was retrieved from HIS. The Analysis was done using Epi Info software.Results: Out of 300 population studied there were 250 patients having positive history out of them only any single parameter alteration was found in total 148 patients; two parameter alteration in 83 patients, three parameter alteration in 10 patient, and four parameter alteration in 6 patients.Conclusion: Because very few cases were found to have derangement of multiple parameters of the lipid panel, hence it seems that screening with most frequently affected marker like HDL-c and TG only for screening may be considered in this population.