Background: World Health Organization (WHO) defines Self-Medication as ‘the selection and use of medicines by individuals to treat self-recognized illnesses or symptoms’ or by health personnel such as the self-prescription of drugs not prescribed by a doctor. Methodology: A Cross-Sectional observational study was done with the help of a semi-structured detailed questionnaire in English and Hindi which was filled by the subjects. Results: Out of the total 103 responses, 59 (57.3%) women were working whereas 44 (42.7%) were non-working Peri-menopausal females. There were 54 (91.5%) working and 36 (81.8%) non-working females who had taken medication without proper prescription for them. Most common reason for self-medication was fever (83.3%) for both the groups. Most of the women got these self medicines by directly requesting it from the pharmacy [64 (71.9%)].Majority of the peri-menopausal females [85 (89.5%)] didn’t go to a doctor because of the non seriousness of the symptoms. Discussion: In our study out of the total 103 participants, 59 were working females and 44 were non-working females. Working females took a larger amount of allopathic and homeopathic medicines while the non-working females took more ayurvedic and unani medicines. Also more number of working females were aware of the risks associated with self-medication as compared to the non-working females. Conclusion-The result reflects the various differences in pattern, attitude and behavior of peri-menopausal women on the practice of self-medication. In our study both working women and housewives of peri-menopausal age group were found to be indulged in self-medication which may lead to incorrect diagnosis. Most common reason for self-medication was fever and the drugs used were the anti-pyretics. Study also reveals need of education related to safe use of medicines, strict regulatory actions regarding over the counter availability of drugs.