Background: The aim was to study the acceptability, efficacy side effects of injection of Depot Medroxy-progesterone acetate (Injection Antara) as contraceptive in reproductive age group woman in postpartum and interval and post abortal period. Methods: The present study was a retrospective study conducted in department of OBG, Anantapuram, Govt Medical College, Anantapuramu, Andrapradesh. 450 women taken counselling and 155 members accepted to take injection during period of Jan 2022 to Dec 2023. At time of injection DMPA 1st dose card issued to the women where her particulars weight, blood pressure, menstrual complaints were recorded and date of next visit also mentioned. Results: 450 women taken proper counselling but 155 women enrolled for taking injections.Inj. DMPA as contraception acceptability rate 34.4% and continuation rate for further dose 18.75% for 4th dose maximum in postpartum period. Menstrual irregularities most common cause for discontinuation 31.6% minor side-effects weight gain 3.8% mood changes 0.6%. Conclusion: Breastfeeding after delivery more women think as naturally, they don’t opt for contraception method and they come after 6 months after delivery. Post abortal patient not taking any contraceptive as they are waiting next conception. Educate the patient in antenatal period for contraceptives advice after delivery. There is a need to create awareness regarding the harmless side-effects. Women who are counseled about side-effects are less likely to discontinue their use, more likely satisfied users and eventually become its best promoter as reversible contraceptive.