Background: The lower portion of the oesophagus, the tube that joins the throat and stomach, has enlarged, bulging veins called oesophageal varices. The present study was evaluated prediction of large oesophageal varices in patients with cirrhosis of liver. Materials & Methods: 70 patients with cirrhosis of liver of both genders were selected. The existence and severity of encephalopathy and ascites were evaluated using the Child-Pugh criteria. EV's size and presence were noted. The parameters put forward at the Baveno I Consensus Conference were used to classify the size of varices into two classes: small and large. Results: Out of 70 patients, 38 were males and 32 were females. Causes of cirrhosis of liver was alcohol in 49, hepatitis B in 16 and others in 5 cases. The difference was significant (P< 0.05).Child Pugh score was 7.5, albumin was 34.6 g/L, ALT was 42.3 IU/L and total bilirubin level was 28.4 μmol/L. The mean age was 55.1 years and 56.2 years, there were 70.2% male and 68% male, Child- Pugh score was 7.3 and 9.2, albumin level was 32.5 g/L and 34.8 g/L, ALT was 44.1 IU/L and 45.9 IU/L and total bilirubin level was 29.3 μmol/L and 34.6 μmol/L in patients with no or small varices and in patients with large varices respectively. The difference was non- significant (P> 0.05). Conclusion: Large oesophageal varices may be predicted by the Child-Pugh score, total bilirubin, and albumin level in patients with liver cirrhosis. Therefore, the estimation of patients with liver cirrhosis may yield valuable information, guaranteeing their occurrence is prevented.