Aim: This study aims to evaluate the postoperative histopathological changes in excised tissues following the administration of different anestheticagentssevoflurane, propofol, and desflurane. The study examines cellular alterations, inflammatory response, and potential complications to determine whether anesthetic choice influences tissue integrity and healing outcomes. Materials and Methods: A prospective analysis was conducted on 100 patients undergoing elective surgeries under general anesthesia. Patients were randomly assigned to one of three groups based on the anesthetic agent used: sevoflurane (n=34), propofol (n=33), or desflurane (n=33). Tissue samples were collected during surgery, fixed in 10% buffered formalin, and processed for histopathological evaluation. Key parameters analyzed included nuclear atypia, inflammatory response, tissue necrosis, and vascular alterations. Systemic inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were also assessed. Results: The demographic and clinical characteristics of the three groups were comparable, with no significant differences in age, gender distribution, or ASA classification. Histopathological examination revealed no significant differences in nuclear atypia (p=0.78), inflammatory response (p=0.65), tissue necrosis (p=0.74), or vascular alterations (p=0.69) across the three groups. Postoperative inflammatory markers, including CRP (p=0.72), IL-6 (p=0.68), and TNF-α (p=0.81), showed no statistically significant variations. Postoperative complications, such as wound infections (p=0.88), delayed healing (p=0.71), and hematoma formation (p=0.76), were also similar among groups. The duration of surgery and anesthesia did not differ significantly (p=0.84 and p=0.79, respectively). Conclusion: Sevoflurane, propofol, and desflurane exhibit comparable effects on postoperative histopathological changes, inflammatory responses, and complication rates. No significant differences were observed in nuclear atypia, inflammatory response, tissue necrosis, or vascular alterations. Inflammatory markers remained similar across groups, indicating no major differences in systemic inflammatory modulation. Given the comparable postoperative outcomes, this study suggests that the choice of anesthetic agent does not substantially impact tissue integrity or recovery.