Background:Acne vulgaris is a common skin disorder that mainly affects the face but can also affect the back and chest. It can cause inflammatory and non-inflammatory lesions as well as varying degrees of scarring. The present study compared fractional carbon dioxide laser technique and derma roller therapy in patients with post-acne scars.Materials & Methods:Two groups of 35 patients each were created from 70 individuals with post-acne scars of both sexes. Patients in Group I received derma roller therapy, while the other group had fractional CO2 laser treatment every four weeks for a total of twenty-four weeks. The global acne scarring categorization was used for a baseline assessment of each patient, which was both objective and subjective.Results: Response was satisfactory seen in 6 in group I and 3 in group II, good in 7 and 11 in group I, very good in 16 in group I and 14 in group II and excellent in 6 in group I and 7 in group II. The difference was significant (P< 0.05). The mean objective score at baseline in group I was 30.2 and at follow up was 16.4 and in group II at baseline was 29.7 and at follow up was 16.1. The difference was significant (P< 0.05).Conclusion: It was demonstrated that both methods were equally effective in treating scars from acne.