Original Articles
Comparative Analysis of Three Cytological Grading Systems in Fine-Needle Aspiration of Breast Carcinoma | |
Dr. Rahat Un Nisa, Dr. Navneet Naz | |
Background: Breast carcinoma is a heterogeneous disease with varying clinical and pathological characteristics. Tumor grading plays a crucial role in prognostication and therapeutic decision-making. This study evaluates the age distribution, site of lumps, and tumor grading using multiple cytological and histological grading systems to highlight their importance in clinical practice. Methods: This present study included patients diagnosed with breast carcinoma. The age distribution of participants was analyzed, and the location of breast lumps was documented. Tumors were graded using Robinson’s, Fisher’s, Howell’s, and Scarff-Bloom-Richardson (SBR) systems to assess concordance and clinical significance. Results: The mean age of participants was 51.12 years, with a standard deviation of ±12.024 years. The majority (38.3%) were aged 51–60 years, with 23.3% aged 41–50 years. Breast lumps were most commonly located in the upper outer quadrant (81.7%), followed by the upper inner quadrant (10%). Tumor grading showed that Grade 2 tumors predominated across all systems: 55.0% in Robinson’s, 51.7% in Fisher’s, 56.7% in Howell’s, and 55.0% in SBR grading. Grade 1 tumors ranged from 18.3% to 28.3%, while Grade 3 tumors varied between 18.3% and 26.7%. Conclusion: The study emphasizes the importance of tumor grading in breast carcinoma as a cost-effective and reliable prognostic tool, especially in resource-limited settings. The predominance of Grade 2 tumors across all grading systems underscores their clinical relevance in guiding treatment. The anatomical distribution of lumps and demographic patterns further support targeted screening and management strategies. |
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