Background: Acute pancreatitis is a potentially fatal inflammatory condition of the pancreas that can infiltrate distant organ systems or regional tissues in different ways. Plasma levels of the acute phase protein CRP rise in almost all acute and chronic inflammatory conditions. The present study was conducted to evaluate the prognostic value of C-reactive protein in acute pancreatitis an experience from tertiary care centre in South India. Methods: The present retrospective diagnostic test evaluation study was conducted among all the 230 patients admitted with acute pancreatitis in the Surgical Department of Government Medical College, Ernakulam for the last of 5 yrs. Ranson’s scoring system, and serum CRP assays (CRP >9.6mg/dl in the 1st 48hours and Ranson’s score of > or = 3 as cut-off). C-reactive protein was estimated by using latex agglutination test on the day of admission or the next day. Results were analyzed using SPSS version 25.0. Results: Maximum patients were in the age group of 31-40 years 81 (35%) and least were in the age group of 18-20 years 12 (5%). Number of male patients were 138 (60%) and female were 92 (40%). The most common etiology was alcohol (85%) followed by gall stones (10%), Cyst (3%) and viral infection (2%). 184 (80%) had ranson score <3 while 46 (20%) patients had score ≥3 as shown in table 2. 182 (78%) patients had CRP value <9.6 and 48 (22%) had CRP values ≥ 9.6. 11 (4.7%) patients died and 219 (95.3%) were discharged from hospital. Sensitivity, specificity, PPV, NPV and accuracy values for Ranson score were 79.6%, 81%, 64.5%,87.6% and 80.3% whereas for CRP were 86.7%,76.3%, 66.9%, 91.1% and81.9% Conclusion: The disease known as acute pancreatitis can be fatal and presents with a variety of symptoms. Previous research on C Reactive Protein as a predictive marker has produced encouraging findings. To lower the mortality and morbidity linked to acute pancreatitis, more research on its function is required.