Background: One of the biggest environmental problems of our day is air pollution. Growing industrialization exposes the average person to toxins that have a negative impact on his health in both developed and developing nations. The present study assessed the effect of yoga practices on selected proinflammatory and anti-inflammatory cytokine. Materials & Methods: 80 healthy subjects of both genderswere divided into 2 groups of 40 each. In group I, subjects performed yoga intervention for a period of three months. Each yoga session was conducted for 45 min, six days a week, for 12 weeks, excluding weekly holidays. Group II (control) did not undergo any yoga training and continued with their daily schedule. A 5 ml venous blood samples were collected at the baseline and after three months.The level of proinflammatory and anti-inflammatory cytokines was measured. Results: Group I had 18 males and 22 females and group II had 20 males and 20 females. The mean age was 41.2 years in group I and 40.2 years in group II. The mean weight was 63.7 kgs in group I and 61.4 kgs in group II, height was 162.0 cms in group I and 163.2 cms in group II, BMI was 23.8 Kg/m2 in group I and 22.8 Kg/m2 in group II. The difference was significant (P< 0.05). Pre and post IL-1β level in group I was 0.74 and 0.52 and in group II was 0.82 and 0.92. IL- 10 level was 3.1 and 6.4 and in group II was 3.4 and 2.7 respectively. Conclusion: According to the current study, those who practice yoga may have lower levels of pro-inflammatory and higher levels of anti-inflammatory cytokines.