Background: In India, alcoholism is a severe problem, with a prevalence of 19–34% on average over a 12-month period. Alcoholics can return to normalcy with early discovery, appropriate medicine, and counseling, but they frequently cleverly conceal their illness and see doctors much later, which has serious socioeconomic repercussions.The present study assessedusefulness of Carbohydrate Deficient Transferrin (CDT) as a sensitive marker to diagnose alcohol abuse. Materials & Methods: 45 alcoholics of both genders were selected. Group I comprised of alcoholics and group II had control. Liver function tests and Carbohydrate Deficient Transferrin was assessed. Results: In group Iand group II, meanplasma glucose level was 104.2mg/ dl and 106.3mg/ dl, AST level was 42.5IU/L and 32.5IU/L, ALT was 29.6IU/L and 21.9IU/L, ALP was 152.3IU/L and 140.6IU/L, T. PROTEINS (g%) was 6.8 and 6.6, albumin (g%) was 3.2 and 3.1, total bilirubin was 0.8mg/dl and 0.7mg/dl, MCV was 106.4fL and 94.2fL, GGT was 58.2U/L and 24.7U/L, CDT was 5.6% and 1.8% respectively. The difference was significant (P< 0.05).Sensitivity, specificity, PPV and NPV for CDT was 85%, 93%, 94% and 81%, for GGT was 65%, 73%, 78% and 69%, for AST was 68%, 80%, 76% and 72%, for ALT was 34%, 91%, 80% and 69% and for MCV was 49%, 53%, 56% and 58% respectively. Conclusion: CDT is a sensitive biomarker that is better than GGT in terms of both sensitivity and specificity and can be used to identify alcohol abuse.