Purpose: To determine the proportion of children with improvement in best corrected visual acuity after part time occlusion therapy for anisometropic amblyopia.Methods: This was a prospective observational study on 33 children in the age group of 5 to 15 years with unilateral anisometropic amblyopia. Study period was from November 2018 to March 2020. Part time occlusion was advised when no improvement in visual acuity was noted after spectacle correction for 6 weeks. The duration of occlusion was 4 hours a day for 4 months. Follow up examination was conducted monthly for 4 months.Results: Out of the 33 subjects recruited, 16 children were in the age group of 5 to 8 years (48.5%), 11 children in the age group of 9 to 12 years (33.3%) and 6 were in the age group of 13 to 15 years (18.2%). Mean age was 9.2 +/- 2.8 years. 17 were males and 16 were females. Mean pretreatment best corrected visual acuity was 0.55+/-0.21 log MAR. After 4 months of occlusion therapy, the mean best corrected visual acuity was 0.3+/- 0.27 log MAR. 22 patients (66.7 %) had significant improvement in visual acuity. Children in the younger age group (5 to 12 years) showed maximum improvement.Conclusion: Significant improvement in best corrected visual acuity occurs after part time occlusion therapy for anisometropic amblyopia. Children who are younger respond better to this treatment.