Background: Any uncomfortable emotional experience accompanied by predictable biochemical, physiological, and behavioral changes is the definition of stress. The present study was conducted to assess perceived stress and sleep quality among medical students. Materials & Methods: 240 medical students of both genders were selected. A self-administered questionnaire was distributed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and stress level using the Perceived Stress Scale (PSS). Weight, height and BMI was calculated. Results: Out of 240 students, 110 were males and 130 females. PSQI score <5 was seen in 145, 5-7 in 62 and >7 in 33 students. PSS score 0-13 (low stress) was seen in 72, 14-26 (moderate stress) in 138 and 27-56 (high stress) in 30. The difference was significant (P< 0.05). There was no significant correlation between PSQI distribution and BMI (P> 0.05). Conclusion: Most of the individuals slept well and experienced modest levels of stress. Nonetheless, a strong relationship between stress level and sleep quality was found. It's interesting to note that there was no relationship between body fat or BMI and sleep quality.