Abstract Issue

Volume 14 Issue 2 (February) 2025

Case Reports

Primary Adrenal Insufficiency Presenting with Primary Hypogonadism
Dr. Mihir Gordhanbhai Patel, Dr. Jeet Prafulbhai Patel, Dr. Parit Mukeshbhai Zalavadia

Addison’s disease is a rare endocrine disorder affecting adrenal function, leading to reduced cortisol and aldosterone production (Husebye et al., 2014). Primary hypogonadism in men results from testicular dysfunction, causing low testosterone levels and elevated gonadotropins (Wu et al., 2008). The simultaneous occurrence of both conditions is extremely rare. This case study presents a 56-year-old male with symptoms of generalized weakness, salt cravings, gynecomastia, and sexual dysfunction. The patient had a history of incomplete tuberculosis treatment and underwent left-sided orchiectomy for a testicular abscess. Laboratory investigations confirmed primary adrenal insufficiency and primary hypogonadism. Imaging revealed adrenal calcifications, suggesting a tubercular etiology. The patient was treated with hydrocortisone, fludrocortisone, and testosterone replacement therapy, resulting in significant clinical improvement. This case highlights the importance of recognizing endocrine dysfunction in patients with a history of tuberculosis and emphasizes the role of comprehensive hormone replacement therapy in management.

 
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