Original Articles
Pathophysiology of juvenile gastrointestinal polyps and the role of stromal eosinophilic infiltration | |
Dr. Anil Lodhi, Dr. Maneesh Goyal, Dr. Shilpa Tomar | |
Background: In children, intestinal polyps are often observed; the most prevalent kind, found in about 90% of individuals, are juvenile polyps. In young polyps, mucosal eosinophilia is very important. A thorough understanding of these conditions is essential to guarantee proper care and follow-up. Aim: The objective of this study was to determine the location and histology of intestinal polyps as well as the role that stromal eosinophilia plays in the pathophysiology of juvenile polyps. Methods: Eighty-four children with gastrointestinal polyps were evaluated in this study. Each subject's polyp location, quantity, and size were evaluated. Also, the correlation between size/age and stromal eosinophilia was examined in participants with juvenile polyps. The data obtained were examined statistically. Results: The current study findings demonstrate that out of 84 participants6, 6, 4, and 8 participants are with inflammatory polyps, Peutz Jeghers polyp, juvenile polyposis coli, and solitary juvenile polyps, respectively, had eosinophilic infiltration of less than 20/HPF and 0, 0, 0, and 60 individuals with Peutz Jeghers polyp, juvenile polyposis coli, inflammatory polyps, and isolated juvenile polyps, respectively, had eosinophilic infiltration of >20/HPF. The research participants' mean age was 6.5 years, and the rectum was the most often found location for polyps. There was a negative association between the age of juvenile polyps and eosinophilic infiltration and a positive correlation with polyp size. Conclusion: The current study finds that single juvenile polyps account for the bulk of the gastrointestinal polyps seen in the kid patients. The potential involvement of allergies in the etiopathogenesis of juvenile polyps may be illustrated by large eosinophilic infiltration of gastrointestinal polyps. |
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