Background: The presence of immature lungs in fetuses has been linked with various negative consequences including RDS (respiratory distress syndrome). The ability to postpone or continuation of birth is usually the deciding factor that efficiently assesses fetal lung maturity. Aim: The present study aimed to assess the value of the evaluation of amniotic fluid utilizing the ultrasonography for prediction of fetal lung maturity and its effect on fetal outcomes. Methods: The present study assessed 300 females that were pregnant females who visited the institute within the defined study period. These 300 pregnant females were then divided into two groups Group I included subjects that had RDS in the fetus and Group II included subjects whose fetuses did not have RDS. The data gathered were analyzed statistically. Results: The results of the present study showed the presence of a significant difference in RDS as well as non-RDS group concerning gestational age with p=0.0005. However, no significant difference was seen in RDS and non-RDS fetuses concerning abortion, parity, gravidity, and maternal age with p>0.05. Concerning fetal biometric assessment, study results showed a significant decrease in fetal biometric measurement values including AC, FL, and BPD in the RDS group compared to non-RDS fetuses with p<0.001. Conclusion: The present study concludes that ultrasound variables including amniotic FFP (fluid-free floating particles), DFE (distal femoral epiphysis), and PTE (proximal tibial epiphysis) are vital and accurate predictors for the assessment of respiratory distress syndrome with different degrees of performance.